Brenda M. Ryals, Ph.D.

Professor

Office: HHS 1129
Phone: 568-3871
Email: ryalsbm@jmu.ed

Research and Teaching Areas

Anatomy and Physiology of the Auditory System
Auditory plasticity in the periphery - hair cell regeneration
Central auditory system plasticity as a function of hair cell regeneration or deprivation

Research Laboratory

Auditory Research Laboratory

Current and Ongoing Research Projects

Functional consequences o f hair cell regeneration
Afferent and efferent hair cell innervation patterns after regeneration or during development in hereditary hearing loss
Central auditory system re-organization in an avian model with ongoing hair cell regeneration and hereditary hearing loss

Publications (last five years)

Matsui, J. and Ryals, BM (2005 in revision) Hair cell regeneration: An exciting phenomenon, but will it be possible to restore hearing and balance? Journal of Rehabilitation Research and Development.

Ryals, BM, Cunningham, L, A Primer on Biology of Hair Cell Regeneration, Rescue and Repair, Seminars in Hearing, 24(2):99-110, 2003.

Wilkins, HR, Presson JC, Dooling RJ, Ryals BM, Popper AN, Apoptotic hair cell death in a hearing-deficient canary, Journal of the Association for Research in Otolaryngology, 2/1:079-086, 2001

Gleich, O., Dooling RJ, Ryals, BM. A quantitative analysis of the nerve fibers in the VIIIth nerve of Belgian Waterslager canaries with a hereditary sensorineural hearing loss, Hearing Research 151:141-148, 2001

Ryals, B.M. and Dooling, R.J, Discussion: Changes in vocal production and auditory perception after hair cell regeneration, J. Communication Disorders; 33(4):313-319, 2000

Gleich, O. Dooling R.J. and Ryals BM , Neither Endocochlear Potential nor Tegmentum Vasculosum are affected in hearing impaired Belgian Waterslager Canaries ; Hearing Research 142:56-62, 2000

National and International Conference Presentations (last five years)

Ryals, BM, Sanaovich, E., Petralia, R. and Dooling RJ TEM Analysis Of Innervation Patterns On Hair Cells In Normal Canary And A Canary With Progressive, Genetic, Inner Ear Abnormality (Belgian Waterslager Canary); Assoc. for Res. In Otol., abs. 28:454, 2005

Ryals, BM, Sanovitch E, and Dooling RJ; Synaptic Innervation Patterns On Hair Cells In Hatchling And Adult Belgian Waterslager (BWS) Canary; Assoc. for Res. In Otol. , abs. 27:732, 2004

Ryals BM, and Cunningham, Biological Bases for Regeneration and Repair, American Academy of Audiology, abs. IC603, pp.68, 2004

Lee, J. and Ryals, BM, Stereocilia orientation and return of function in regenerated hair cells, American Speech Hearing Language Association, abs. 82, pp. 86 ASHA Leader 2003

Elizabeth F. Brittan-Powell, Amanda Lauer, Robert J. Dooling, and Brenda M. Ryals, Far-field neural population responses in Belgian Waterslager (BWS) canaries, Assoc. for Res. In Otol. , abs. 26:171, 2003

Ryals, BM and Dooling, RJ: The Functional Significance of Hair Cell Regeneration on Auditory Perception and Vocal Production, IHCON, pp. 14, 2002.

Ryals, BM and Dooling RJ, Development Of Hair Cell Stereovilli Bundle Abnormalities In Belgian Waterslager Canary, Assoc. for Res. In Otol. Abs.25:942, 2002

Brittan-Powell EF, Dooling RJ, Wright T, Mundinger PC, Ryals,BM, Development of auditory sensitivity in Belgian Waterslager (BWS) canaries, , Assoc. for Res. In Otol. Abs.25:947, 2002

Ryals, BM, Tucker TS, Inner ear abnormalities in Belgian Waterslager canary are not congenital, AAS Bulletin 26:25, 2001

Ryals, BM, Gleich, O, Tucker, T. Inner ear abnormalities in Belgian Waterslager Canary are not congenital, Assoc. for Res. In Otol. Abs.24:777, 2001

Ryals, B.M., Myosin VIIa expression in a bird with hereditary Deafness, Bulletin of the American Auditory Society 25(1):98. 2000

Ryals, B.M., Gleich, O., Tucker, T Myosin VIIa expression during continuous hair cell regeneration in Belgian Waterslager canaries, Assoc. for Res. In Otol. Abs.23:833, 2000

Ryals, BM. (moderator and panelist) special Symposium sponsored by ASHA at the national convention of the American Academy for the Advancement of Science: "Restoring Damaged Inner Ear Hair Cells and Their Neural Connections", Speakers J. Stone U. Washington, N. Segil House Ear Inst. And S. Green, Univ. Iowa, Feb. 2005

Ryals, BM. "Recent Insights into Hair Cell Regeneration" invited speaker at the Military Audiology Short Course, 2005

Herer, G., Glattke, T., Montgomery,J., Ryals, B. and Bentler, R., Hearing Loss, Mental retardation or Both?"poster presentation, American Speech Language Hearing Association, November 2004

Ryals, BM and Cotanche, D "Hair Cell regeneration in the inner ear" Web enhanced Teleseminar, American Speech Language Hearing Association, 2004.

Ryals, BM. . "Hair Cell Regeneration: A 15 Year update" 5th Biennial Audiology Symposium: Innovations in Hearing" at the Cleveland Clinic , 2004

Ryals, BM. "Do hair cells regenerated in adulthood restore hearing?" Massachusets Eye and Ear Infirmary, Harvard University, May 2004.

Ryals, BM. "Hair cell regeneration 16 Years Later: Lessons from cellular and molecular biology, Keynote Speaker, Alaska State Speech and Hearing convention, 2004

Ryals, BM, Hair cell regeneration: What we are learning from Molecular Biology, Genetics and Cancer Research, keynote speaker Colorado Academy of Audiology annual meeting, 2001

Ryals, BM, Functional Consequences of Hair Cell Regeneration: Insights from the World of Animal Communication, keynote speaker 8th Annual Sol Adler Conference, University of Tennessee, 2001

Ryals, BM, Biological bases for hair cell regeneration, rescue and repair, American Speech Language Hearing Association, annual meeting 2001

Ryals, BM, Does function follow form? Or, now that it looks right, does it work? Invited faculty, "Biology of Noise Induced Hearing Loss: Mechanisms of Injury, Recovery, Protection" Seattle WA Sept. 5-8, 2001.

Ryals, BM, Hair cell regeneration and the restoration of hearing, guest lecturer, Women in Science and Engineering Program, Syracuse University April 11-12, 2001

Ryals, BM, A Primer on Biology, presented at the CID Conference "New Frontiers in the amelioration of Hearing Loss, March 22-25, 2001

Wehman, KJ.,Snorrason, R, Ryals, BM., Morphological correlates of improved hearing in Belgian Waterslager Canaries, American Speech Language Hearing Association, annual meeting 2000

Ryals, BM., Cunningham, L. Suicide Prevention for Cochlear Hair Cells American Speech Language Hearing Association, annual meeting 2000